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Arterial vascular volume changes with haemodynamics in schistosomiasis-associated pulmonary arterial hypertension
PDPI Jatim, 04 Jun 2021 06:50:29

Extract

Schistosomiasis is a prevalent cause of pulmonary arterial hypertension (PAH), currently classified as group 1 pulmonary hypertension (PH) [1]. In comparison to other aetiologies of PAH, such as idiopathic PAH, schistosomiasis-associated PAH (Sch-PAH) has not been extensively studied. Potential mechanisms of PAH development in schistosomiasis include systemic and localised lung inflammation, involvement of other organs, such as the liver and spleen, and direct blockage of precapillary vessels from parasite egg embolisation. Currently, the diagnosis of Sch-PAH relies on haemodynamic assessment using right heart catheterisation. In several aetiologies of PH, loss of visualised distal vascular volume has been quantified from pulmonary angiography [2, 3] and computed tomography (CT) of the lungs [4–6]. Additionally, loss of distal vascular volume has been shown to be associated with loss of vascular cross-sectional area histologically [7]. In this pilot study, we hypothesised that relative loss of arterial pulmonary vascular volume differentially correlates with haemodynamics in Sch-PAH patients, compared to a group of control subjects.

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