Keya Rani Lahiri1, Fehmida
Najmuddin1 and Khushal Avasthi2
1Pediatrics,
D Y Patil School of Medicine, Hospital, Navi Mumbai, MaharashtraIndia,
2Pediatrics, D Y Patil School of Medicine, Navi Mumbai, MaharashtraIndia
INTRODUCTION:
Deficiency of Vitamin D in the Indian subcontinent is emerging as a
major non- infectious epidemic.
AIMS&OBJECTIVES:
To study 25(OH) vitamin D levels in children with asthma and allergic
rhinitis and to correlate with classification and pulmonary function
tests.
MATERIAL & METHODS:
We studied 66 children with asthma and allergic rhinitis between 6 to
12 years of whom 33 cases were administered Vitamin D and 33 controls
who were not given Vitamin D. The ethical committee approval was taken.
It was a prospective, randomised and comparative study. Data was
analysed using mean, standard deviation and paired- t test.
RESULTS: The study
revealed 42 (63.6%) males and 24(36.4%) females .The Asthma
classification depicted mild persistent in 37(56.1%) followed by
intermittent 16(24.2%) and moderate persistent 12(18.2%).Maximum cases
of allergic rhinitis were moderate persistent 42 (63.6%). Amongst the
66 patients 43(65.2%) were deficient, 18(27.3%) insufficient and
5(7.6%) normal. The severity of asthma and allergic rhinitis did not
correlate with Vitamin D deficiency. Children who received vitamin D
had significant values of Forced Expiratory Volume in the first second
(FEV1, p-0.000), Forced Vital Capacity (FVC, p-0.005), FEV1: FVC
(p-0.002) and Peak Expiratory Flow Rate (PEFR, p-0.000). The control
group showed significant values in the PEFR parameter (p- 0.0077).
CONCLUSION: The
study highlighted 61(92.5%) children had abnormal Vitamin D levels. The
case group showed marked improvement in the lung functions. Adherence
to the duration of therapy for a period of 10 weeks with Vitamin D is
mandatory.
Source
: http://erj.ersjournals.com/content/48/suppl_60/PA1244
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